Xenotransplantation

NuketheplaceNuketheplace Join Date: 2002-09-02 Member: 1266Members
<div class="IPBDescription">and its ethical implications</div> I was wondering what everyone here thought about xenotransplantation and its pros and cons. On the one hand it could save thousands of lives a year, on the other it could introduce a new virus into the world. Two very different sides. Do you all think we should go ahead with human tests, or stop testing it all together?

For those of you who don't know here is a <a href='http://en.wikipedia.org/wiki/Xenotransplantation' target='_blank'>wikipedia link</a> to get you started. Its basically taking the organ of one creature and putting it into another. The most suggested type is pigs to humans.

Comments

  • SandstormSandstorm Join Date: 2003-09-25 Member: 21205Members
    I doubt you can just replace any organ with an animal one, as there must be an incredibly high probability the body will reject it, considering the chances that other HUMAN organs have for succeeding. I personally think it would be easier to focus on artifical organs.
  • NuketheplaceNuketheplace Join Date: 2002-09-02 Member: 1266Members
    Yah, thats true. Most people that have under gone Xenotransplantation only live about 24 hours. The longest case was around 7 months. However, eventually we will have the ability to supress our immune system to the point were Xenotransplantation can happen. Right now this is a hypothetical debate, but it could very soon become a real one. So the question still stands, what do you think?
  • AegeriAegeri Join Date: 2003-02-13 Member: 13486Members
    <!--QuoteBegin--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> </td></tr><tr><td id='QUOTE'><!--QuoteEBegin-->as there must be an incredibly high probability the body will reject it, considering the chances that other HUMAN organs have for succeeding.<!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->

    Not exactly true, because there has already been some work done on genetically engineering organs from animals so they become more 'human' like for transplantation purposes.

    For example, pig organs have been made that lack the cell surface sugar alpha-1,3-galactosyltransferase because this rapidly turns on the immune system (leading to hyperacute rejection). Normally the rejection is in hours, but now we can extend that onto days (which is an achievement). Further work has focussed on making organs that are harder to reject because they do not transmit danger signals (From accompanied pig retroviruses) and have modified MHC molecules that are more 'human like' but that aren't able to activate immune response.
  • lolfighterlolfighter Snark, Dire Join Date: 2003-04-20 Member: 15693Members
    It'll be branded "unnatural," mark my words. Which leads me to question the concept of "natural." What exactly IS natural, and how come we humans are not included in it?

    Think about it: If we are part of nature (and I dare you to claim otherwise without having VERY compelling arguments), then whatever we do or create is also a part of nature. I.e. a nuclear power plant is natural. Otherwise, any kind of artificial construct, like an ant hill, would be unnatural as well. And I don't see anything wrong with an ant hill, personally.

    So in short: If you're going to call it unnatural, think long and hard about your definition of unnatural and how you are going to defend it, and specifically about why something being unnatural actually matters.
  • MetalcatMetalcat Join Date: 2004-08-11 Member: 30528Members
    i say lets do it, it would save alot of people, but what about overpopulating the planet then?

    and about the workless % OH NO
  • Status_QuoStatus_Quo Join Date: 2004-01-30 Member: 25749Members
    Meh. If it works and someone wants to do it, let them. It doesn't hurt anyone (well, except the pig or whatever, but there seems to be very little moral outrage about slaughtering pigs for other, less important reasons).
  • CyndaneCyndane Join Date: 2003-11-15 Member: 22913Members
    I'm sure some loud mouths at PETA would get their perverbial panties in a bunch over this. <!--emo&:(--><img src='http://www.unknownworlds.com/forums/html/emoticons/sad-fix.gif' border='0' style='vertical-align:middle' alt='sad-fix.gif' /><!--endemo-->
  • ThansalThansal The New Scum Join Date: 2002-08-22 Member: 1215Members, Constellation
    PETA is a nonissue. They have made a mockery of them selfs to often for most people to take them seriously.

    The real poposition would be those that look at it as unnatural.

    Personaly?
    If it works do it.
    If there is a threat of outbreaks of things like PERV, then we definatly have to legallize it. Why?

    If we make it illegal then people will simply go to other countries, and we will have no documentation, no way to watch over these people.

    If we do it in-country then we can keep tabs on these people, force them to take the regular blood tests etc etc
  • pieceofsoappieceofsoap Join Date: 2002-11-21 Member: 9535Members, Constellation
    Honestly, we kill them for food all the time, I dont think the ethical ramifications of killing Organ Pigs are that much different.

    Now, in regards to Xenotransplantation, in my opinion, if it works, go with it. If humanity is exposed to new diseases through it, we are simply faced with new hurdles to overcome, and Im pretty confident that we could make it through the worst case scenario.
  • CyndaneCyndane Join Date: 2003-11-15 Member: 22913Members
    Yes, but soap if it fails, we could have Zombies, and I don't have the zombie survival guide <!--emo&:(--><img src='http://www.unknownworlds.com/forums/html/emoticons/sad-fix.gif' border='0' style='vertical-align:middle' alt='sad-fix.gif' /><!--endemo-->

    *Puppy-dog eyes*

    I need a "big, strong, and handsome man" to come and save me. *wink wink*
  • SkySky Join Date: 2004-04-23 Member: 28131Members
    <!--QuoteBegin-Nuketheplace+Jun 3 2005, 02:55 AM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Nuketheplace @ Jun 3 2005, 02:55 AM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> <b>Most people that have under gone Xenotransplantation only live about 24 hours. The longest case was around 7 months.</b> However, eventually we will have the ability to supress our immune system to the point were Xenotransplantation can happen. Right now this is a hypothetical debate, but it could very soon become a real one. So the question still stands, what do you think? <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    That's a damn good indication our body is giving us that we shouldn't be doing this...if your body rejects something, generally it means something isn't right. "Suppressing" the immune system won't make that "something" right.
  • pieceofsoappieceofsoap Join Date: 2002-11-21 Member: 9535Members, Constellation
    <!--QuoteBegin-Sky+Jun 3 2005, 02:58 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Sky @ Jun 3 2005, 02:58 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> <!--QuoteBegin-Nuketheplace+Jun 3 2005, 02:55 AM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Nuketheplace @ Jun 3 2005, 02:55 AM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> <b>Most people that have under gone Xenotransplantation only live about 24 hours.  The longest case was around 7 months.</b>  However, eventually we will have the ability to supress our immune system to the point were Xenotransplantation can happen.  Right now this is a hypothetical debate, but it could very soon become a real one.  So the question still stands, what do you think? <!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->
    That's a damn good indication our body is giving us that we shouldn't be doing this...if your body rejects something, generally it means something isn't right. "Suppressing" the immune system won't make that "something" right. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    Then again, look at allergies, sometimes our bodies dont know what is really best. What we need, in this situation, is to reach a point where the immune system actively accepts the new organ, rather than having to suppress a reaction.
  • lolfighterlolfighter Snark, Dire Join Date: 2003-04-20 Member: 15693Members
    edited June 2005
    <!--QuoteBegin-Sky+Jun 3 2005, 09:58 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (Sky @ Jun 3 2005, 09:58 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin-->That's a damn good indication our body is giving us that we shouldn't be doing this...if your body rejects something, generally it means something isn't right. "Suppressing" the immune system won't make that "something" right.<!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->
    Not true. Without <a href='http://en.wikipedia.org/wiki/Immunosuppression' target='_blank'>immunosuppression</a> (medical suppression of the immune system), rejection of a transplanted organ would be fairly common, leading not only to the death of the transplanted organ, but also to the death of the patient due to infection caused by the decay of the necrotic organ. Yet the general agreement is that a kidney transplant is preferrable to hour-long dialysis therapy three days a week.

    The human body is an incredible organism, but it is in no way intelligent. The intelligent part of our body, the brain, has very little say in the autonomous functions of our body. We can't control our production of red blood cells, for example. We can't tell our white blood cells to not attack the HIV virus (which would be pretty smart I think). We can't tell them to leave that kidney alone because, you know, it may not be part of my original body, but it'll work just like my original kidneys, and if you kill it, I die as well.

    No, sometimes our body does things that are very much counter-productive, and we need to nudge it in the right direction or suppress the part of it that's screwing up.


    Edit: Heck, take <a href='http://en.wikipedia.org/wiki/Autoimmune_disease' target='_blank'>autoimmune diseases,</a> where the immune system decides to attack healthy parts of the body for no apparent reason, and without any outside stimuli. No, the body certainly doesn't always know what's best for us.
  • TommyVercettiTommyVercetti Join Date: 2003-02-10 Member: 13390Members, Constellation, Reinforced - Shadow
    Just like with the "furry gene" thread, I'd rather have cyborg parts.

    In any case, if this works well enough to save lives (permanently) then I'm all for it, at least until they can simply grow the organs in a vat using the patient's DNA.
  • DarkATiDarkATi Revelation 22:17 Join Date: 2003-06-20 Member: 17532Members, Reinforced - Shadow
    I know several people with pig heart valves, they all seem to be doing very well. So, I suppose it's fine. I don't have anything against it. <!--emo&:)--><img src='http://www.unknownworlds.com/forums/html/emoticons/smile-fix.gif' border='0' style='vertical-align:middle' alt='smile-fix.gif' /><!--endemo-->

    ~ DarkATi
  • lolfighterlolfighter Snark, Dire Join Date: 2003-04-20 Member: 15693Members
    <!--QuoteBegin-TommyVercetti+Jun 4 2005, 07:26 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (TommyVercetti @ Jun 4 2005, 07:26 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin-->Just like with the "furry gene" thread, I'd rather have cyborg parts.

    In any case, if this works well enough to save lives (permanently) then I'm all for it, at least until they can simply grow the organs in a vat using the patient's DNA.<!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->
    Which stem cell research would make tremendously easier (or maybe just at all possible). But stem cell research is evil m'kay? After all, that stem cell you're holding there could cure cancer. And who the **** cares that it could do it right now if it could grow up to be a brilliant scientist and do it in fifty years instead?
  • CyndaneCyndane Join Date: 2003-11-15 Member: 22913Members
    <!--QuoteBegin-lolfighter+Jun 4 2005, 05:25 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (lolfighter @ Jun 4 2005, 05:25 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> <!--QuoteBegin-TommyVercetti+Jun 4 2005, 07:26 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (TommyVercetti @ Jun 4 2005, 07:26 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin-->Just like with the "furry gene" thread, I'd rather have cyborg parts.

    In any case, if this works well enough to save lives (permanently) then I'm all for it, at least until they can simply grow the organs in a vat using the patient's DNA.<!--QuoteEnd--></td></tr></table><div class='postcolor'><!--QuoteEEnd-->
    Which stem cell research would make tremendously easier (or maybe just at all possible). But stem cell research is evil m'kay? After all, that stem cell you're holding there could cure cancer. And who the **** cares that it could do it right now if it could grow up to be a brilliant scientist and do it in fifty years instead? <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    Rofl... QFT. :-)
  • lolfighterlolfighter Snark, Dire Join Date: 2003-04-20 Member: 15693Members
    Nothing against you, TommyVercetti, by the way. I'm sorry if it may have seemed so. You didn't mention stem cell research at all, and I have no way to know what your stance is regarding it. So no offense intended - none taken I hope.
  • MantridMantrid Lockpick Join Date: 2003-12-07 Member: 24109Members
    Well, in my book, people not dying = good.
  • TommyVercettiTommyVercetti Join Date: 2003-02-10 Member: 13390Members, Constellation, Reinforced - Shadow
    <!--QuoteBegin-lolfighter+Jun 4 2005, 07:42 PM--></div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td><b>QUOTE</b> (lolfighter @ Jun 4 2005, 07:42 PM)</td></tr><tr><td id='QUOTE'><!--QuoteEBegin--> Nothing against you, TommyVercetti, by the way. I'm sorry if it may have seemed so. You didn't mention stem cell research at all, and I have no way to know what your stance is regarding it. So no offense intended - none taken I hope. <!--QuoteEnd--> </td></tr></table><div class='postcolor'> <!--QuoteEEnd-->
    No offense. I pretty much agree.
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